Scientists and engineers worldwide are battling the COVID-19 pandemic. Here are some examples of their work, including epidemiological analysis, diagnostics, and ventilator models.

Research and Development
Ventilator Resources

COVID-19 Research and Development with MATLAB and Simulink

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COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system

Susanne Rysz et al, Nature Communications, April 23 2021
paper

Face masks effectively limit the probability of SARS-CoV-2 transmission

Yafang Cheng et al, Science, May 20 2021
paper, MATLAB code and data

Data-driven estimation of COVID-19 community prevalence through wastewater-based epidemiology

Xuan Li et al, Science of the Total Environment, October 2021
paper

A model and predictions for COVID-19 considering population behavior and vaccination

Thomas Usherwood et al, Nature: Scientific Reports, June 8 2021
paper

Modelling personal cautiousness during the COVID-19 pandemic: a case study for Turkey and Italy

Hatice Bulut et al, Nonlinear Dyn, February 20 2021
paper

SARS-CoV-2 transmission in educational settings during an early summer epidemic wave in Luxembourg, 2020

Joel Mossong et al, BMC Infectious Diseases, May 4 2021
paper

A network model of Italy shows that intermittent regional strategies can alleviate the COVID-19 epidemic

Fabio Della Rossa et al, Nature Communications, October 9 2020
paper and GitHub MATLAB model repo

Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS-CoV-2 infection

Piyush Nanda and Amit Ghosh, PLOS Computational Biology, April 9 2021
paper

Prediction of Disease Progression of COVID-19 Based upon Machine Learning

F. Xu et al, International Journal of General Medicine, April 29 2021
paper

Sensitivity assessment and optimal economic evaluation of a new COVID-19 compartmental epidemic model with control interventions

Joshua Kiddy K. Asamoah et al, Chaos, Solitons & Fractals, May 2021
paper

Functional profiling of COVID‑19 respiratory tract microbiomes

Niina Haiminen et al, Nature: Scientific Reports, March 19 2021
paper

A novel methodology for epidemic risk assessment of COVID-19 outbreak

A. Pluchino et al, Nature: Scientific Reports, March 5 2021
paper

Toolbox to simulate and mitigate COVID-19 propagation

Zahrate El Oula Frihi et al, SoftwareX, June 2021
paper and GitHub MATLAB code repo

Epidemiological Differences in the Impact of COVID-19 Vaccination in the United States and China

Monia Makhoul et al, Vaccines, March 5 2021
paper

Mathematical model of COVID-19 intervention scenarios for São Paulo—Brazil

Osmar Pinto Neto et al, Nature Communications, January 18 2021
paper and Zenodo code

An extended Weight Kernel Density Estimation model forecasts COVID-19 onset risk and identifies spatiotemporal variations of lockdown effects in China

Wenzhong Shi et al, Communications Biology, 2021
paper and Zenodo code

MSC-NTF (NurOwn®) exosomes: a novel therapeutic modality in the mouse LPS-induced ARDS model

Haggai Kaspi et al, Stem Cell Research & Therapy, January 19 2021
paper

Forecasting of medical equipment demand and outbreak spreading based on deep long short‑term memory network: the COVID‑19 pandemic in Turkey

Erdinç Koç  and Muammer Türkoğlu, Signal, Image and Video Processing, September 8 2020
paper

Retinal findings in patients with COVID-19: Results from the SERPICO-19 study

Alessandro Invernizzi et al, The Lancet, September 20 2020
paper with ARIA - retinal vessel analysis MATLAB code

Modeling Social Distancing Strategies to Prevent SARS-CoV-2 Spread in Israel: A Cost-Effectiveness Analysis

Amir Shlomai et al, Value in Health, December 9 2020
paper

Fast detection of SARS-CoV-2 RNA via the integration of plasmonic thermocycling and fluorescence detection in a portable device

Jiyong Cheong et al, Nature Biomedical Engineering, December 3 2020
paper

In-host Mathematical Modelling of COVID-19 in Humans

Esteban A. Hernandez-Vargas and Jorge X. Velasco-Hernandez, Annual Reviews in Control, September 30 2020
paper

Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19

Shidan Tosif et al, Nature Communications, November 11 2020
paper

Testing sewage to home in on Covid-19

Scott Murray, Institute for Data, Systems, and Society, October 28, 2020
article, paper with MATLAB code

The geography of COVID-19 spread in Italy and implications for the relaxation of confinement measures

Enrico Bertuzzo et al, Nature, August 26 2020
paper

Second Version of a COVID-19 Simulator

Cleve Moler, Cleve's Corner, March 29, 2020
blog post and MATLAB code and app

How to determine when COVID-19 pool testing will be most effective

Behind the Headlines, mathworks.com, August 6 2020
blog post

Short-term prediction of COVID-19 spread using grey rolling model optimized by particle swarm optimization

Zeynep Ceylan, Applied Soft Computing, September 2021
paper

Retrospective methodology to estimate daily infections from deaths (REMEDID) in COVID-19: the Spain case study

David Garcia-Garcia et al, Nature: Scientific Reports, May 28 2021
paper, GitHub MATLAB code

Modeling vaccination rollouts, SARS-CoV-2 variants and the requirement for non-pharmaceutical interventions in Italy

Giulia Giordano et al, Nature Medicine, April 16 2021
paper

Data suggest COVID‑19 afected numbers greatly exceeded detected numbers, in four European countries, as per a delayed SEIQR model

Sankalp Tiwari et al, Nature: Scientific Reports, April 14 2021
paper and GitHub MATLAB repo

Can predicting COVID-19 mortality in a European cohort using only demographic and comorbidity data surpass age-based prediction: An externally validated study

Avishek Chatterjee et al, PLOS One, April 15 2021
paper

A renewal equation model to assess roles and limitations of contact tracing for disease outbreak control

Francesca Scarabel et al, Royal Society Open Science, March 17 2021
paper and GitHub repo

Cognitive impairment and altered cerebral glucose metabolism in the subacute stage of COVID-19

Jonas A Hosp et al, BRAIN: A Journal of Neurology, April 3 2021
paper

Does public fear that bats spread COVID-19 jeopardize bat conservation?

Manman Lu et al, Biological Conservation, February 2021
paper

Real-time tracking and prediction of COVID-19 infection using digital proxies of population mobility and mixing

Kathy Leung et al, Nature Communications, March 8 2021
paper

Optimal Control of Mathematical modeling of the spread of the COVID-19 pandemic with highlighting the negative impact of quarantine on diabetics people with Cost-effectiveness

Abdelfatah Kouidere et al, Chaos, Solitons & Fractals, April 2021
paper

Modelling uncertainty in the relative risk of exposure to the SARS-CoV-2 virus by airborne aerosol transmission in well mixed indoor air

Benjamin Jones et al, Building and Environment, March 15 2021
paper

COVID-19 intervention models: An initial aggressive treatment strategy for controlling the infection

Bismark Oduro and Vusi Mpendulo Magagula, Infect Dis Model, January 23 2021
paper

Controlling COVID-19 Outbreaks with Financial Incentives

Chaeyoung Lee et al, International Journal of Environmental Research and Public Health, January 15 2021
paper

The optimal lockdown intensity for COVID-19

Jonathan P. Caulkins et al, Journal of Mathematical Economics, February 3 2021
paper

A novel Covid-19 and pneumonia classification method based on F-transform

Turker Tuncer et al, Chemometrics and Intelligent Laboratory Systems, March 15 2021
paper

Electricity demand during pandemic times: The case of the COVID-19 in Spain

I. Santiago et al, Energy Policy, January 2021
paper

Optimal COVID-19 quarantine and testing strategies

Chad R. Wells et al, Nature Communications, 2021
paper

Management strategies in a SEIR-type model of COVID 19 community spread

Anca Rǎdulescu et al, Nature: Scientific Reports, December 4 2020
paper

Variation of quantified infection rates of mixed samples to enhance rapid testing during an epidemic

Usama Kadri, Health Systems, September 13 2020
paper

Development of the Intelligent Pneumatic Sewing Platform for Mask Production

Hao-Ting Lin, IEEExplore, July 28 2020
paper

Avoiding COVID-19: Aerosol Guidelines

Matthew Evans, medRxiv, June 5 2020
paper preprint

Multiscale 3-dimensional pathology findings of COVID-19 diseased lung using high-resolution cleared tissue microscopy

Guang Li et al, bioRxiv, April 20, 2020
paper preprint

Mathematical analysis on the dynamics of COVID-19 in India using SIR Epidemic Model

Zargar and Khanday, Mapana Journal of Sciences, August 6 2020
paper

Compartmental Model Suggests Importance of Innate Immune Response to COVID‑19 Infection in Rhesus Macaques

Ericka Mochan et al, Bulletin of Mathematical Biology, May 26 2021
paper

Modeling the cardiac response to hemodynamic changes associated with COVID-19: a computational study

Luca Dede et al, Mathematical Biosciences and Engineering, April 15 2021
paper

Long-term forecasting of the COVID-19 epidemic

The Wellcome Centre for Human Neuroimaging, UCL, 2021
forecast

Vaccination Prioritization Strategies for COVID-19 in Korea: A Mathematical Modeling Approach

Yongin Choi et al, PubMed.gov, April 16 2021
paper

Fleeing lockdown and its impact on the size of epidemic outbreaks in the source and target regions – a COVID-19 lesson

Maria Vittoria Barbarossa, Nature: Scientific Reports, April 29 2021
paper

A single dose of recombinant VSV-ΔG-spike vaccine provides protection against SARS-CoV-2 challenge

Yfat Yahalom-Ronen et al, Nature Communications,
December 16 2020
paper

Infection, inflammation and intervention: mechanistic modelling of epithelial cells in COVID-19

Nabil T. Fadai et al, Journal of the Royal Society Interface, February 17 2021
paper

Seismic evidence of the COVID-19 lockdown measures: a case study from eastern Sicily (Italy)

Andrea Cannata et al, EGU: Solid Earth, February 2 2021
paper

Principal Component Analysis Applications in COVID-19 Genome Sequence Studies

Bo Wang and Lin Jiang, Cognitive Computation, January 13 2021
paper

Comparative cost-effectiveness of SARS-CoV-2 testing strategies in the USA: a modelling study

Zhanwei Du et al, The Lancet: Public Health, February 4 2021
paper

Tracking COVID-19 using online search

Vasileios Lampos et al, NPJ Digital Medicine, February 8 2021
paper

Rapid SARS-CoV-2 Detection and Classification Using Phase Imaging with Computational Specificity

Neha Goswami et al, bioRxiv, December 12 2020
paper preprint

The effect of weather data on the spread of COVID-19 in Jordan

Eman Abdelhafez et al, Environmental Science and Pollution Research, January 9 2021
paper

Design of 3D-printable nasopharyngeal swabs in MATLAB for COVID-19 testing

Yilun Sun et al, Transactions on Additive Manufacturing Meets Medicine, September 9 2020
paper

Automated subject-specific mask design and tissue loading evaluation framework using GIBBON

Kevin Moerman, Twitter, April 2020
post and MATLAB code

Classification of Covid-19 Coronavirus, Pneumonia and Healthy Lungs in CT Scans Using Q-Deformed Entropy and Deep Learning Features

Ali Hasan et al, Entropy, April 2020
paper

A quantitative and qualitative analysis of the COVID-19 pandemic model

Sarbaz Khoshnaw et al, Chaos, Solitons & Fractals, September 2020
paper

First-wave COVID-19 transmissability and severity in China outside Hubei after control measures, and second-wave scenario planning: a modelling impact assessment

Kathy Leung et al, The Lancet, April 8, 2020
paper

A COVID-19 Epidemiological Model for Community and Policy Maker Use

Alex De Visscher, Concordia University, arXiv, March 19, 2020
paper preprint with model code

The math behind epidemics

Alison Hill, Physics Today, November 1 2020
paper, MATLAB code

Influence of wind and relative humidity on the social distancing effectiveness to prevent COVID-19 airborne transmission: A numerical study

Yu Feng et al, Journal of Aerosol Science, September 2020
paper

COVID-19 Spread Predictor

Ahmed Abel-Gawad, MATLAB File Exchange, July 18th
MATLAB code

COVID-19 SimBiology SEIR Model Examples

Fulden Buyukozturk, MATLAB File Exchange, May 29 2020

Cerebral Micro-Structural Changes in COVID-19 Patients – An MRI-based 3-month Follow-up Study

Yiping Lu et al, The Lancet, August 3 2020
paper

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Ventilator Research and Development Resources

These MATLAB and Simulink examples and research papers were used to help with the ventilator shortage. Some are foundational references.

 

An Intensive Push to Make Ventilators for the
COVID-19 Pandemic

Cambridge Consultants, UK

A review of open source ventilators for COVID-19 and future pandemics

Joshua M. Pearce, F1000Research, March 30 2020
paper and MATLAB code for the OxyGEN project

La Inteligencia Artificial y el Machine Learning en los Respiradores Contra el Coronavirus [Spanish]

Ignacio Ozcariz, El Radar de la Georealidad, 6 April 2020
article

COVID-19 Emergency Ventilator

Imperial College London
design, JamVent evaluation of performance

A Simulated Single Ventilator / Dual Patient Ventilation Strategy for Acute Respiratory Distress Syndrome during COVID-19 pandemic

Jose A. Solis-Lemus et al, medRxiv, April 7, 2020
paper preprint

Modelling and Optimisation of Mechanical Ventilation for Critically Ill Patient

Anup Das, University of Exeter, 2012
Ph.D. thesis

Pressure - Volume Controlled Mechanical Ventilator: Modeling and Simulation

Fikret YALÇINKAY, 9th International Conference on Electrical and Electronics Engineering (ELECO), 2015
paper

The BathRC model: a method to estimate flow restrictor size for dual ventilation of dissimilar patients

Andrew Plummer et al, medRxiv, April 17 2020
paper preprint and GitHub repo

Ventilator Example with Closed-Loop Control on Low Cost Hardware

Steve Miller, GitHub, April 2020
GitHub repo with Simulink and Simscape models

Neonatal Ventilator Modeling using Simulink

Ravali K, GitHub, April 2020
GitHub repo with Simulink and Simscape models

Artificial Ventilation Simulator

Jakub R'afl, Czech Technical University in Prague, 2008
Masters thesis

A Novel Methodology for the Design of a Portable Ventilator

Subha Hency Jose P. et al, International Journal of Innovative Technology and Exploring Engineering (IJITEE), November 2019
paper

Medical Ventilator with Lung Model (Simscape Example)

Positive-pressure medical ventilator system that models the lung using Translational Mechanical Converter (MA), which converts moist air pressure into translational motion. 
Simscape model

Modelling and Simulation of Pressure Controlled Mechanical Ventilation System

Noman Q. Al-Naggar, Journal of Biomedical Science and Engineering (JBiSE), 2015
paper

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If you're actively working on an R&D project for COVID-19 and you think MathWorks can help, please contact us.