Projects

gPKPDSimToolbox

An app to enable easy use of any SimBiology-built model to execute common PKPD analyses such as simulation, data fitting, population simulation, and NCA. Includes case studies.

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QSPToolbox

QSP toolbox is a set of functions, structure array conventions, and class definitions that computationally implement critical elements of QSP workflows in an integrated manner.

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Target-Mediated Drug Disposition

Generic Target-Mediated Drug Disposition (TMDD) model that accounts for saturable drug-target binding, as well as target mediated elimination.

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Systemic Renin-Angiotensin-System

Model of the systemic Renin-Angiotensin-System (RAS) to investigate the effects of different RAS-modulating therapies.

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Physiologically-based pharmacokinetics of trichloroethylene

Physiologically based: Human PBPK model for trichloroethylene (TCE) and its metabolites to assess human health risks associated with low level exposure to TCE.

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