SimBiology

フォロー

I am using the simbiology QSP model from H Wang et al., "Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative breast cancer", iScience, 2022. The model includes a drug treatment that works fine with both the SUNDIALS and ODE15s solvers when the dose start time is set to day 0. However, when the dose start time is set to a value later than 0, I encounter the 'Integration Tolerance Not Met' error. The error appears earlier with SUNDIALS; for example, it occurs when the dose start time is set to 7 days. In contrast, the simulation runs without issues using ODE15s until the dose start time is set to 15 days. Surprisingly, with ODE15s, when I reduce the dose amount from 100 units to 20 units, the simulation runs fine with the delayed dose start time set to 40 days. However, if I further delay the dose start time to 50 days, the simulation fails again. Any help will be higly appreciated.