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This project discusses predator-prey system, particularly the Lotka-Volterra equations,which model the interaction between two sprecies: prey and predators. Let's solve the Lotka-Volterra equations numerically and visualize the results.% Define parameters
% Define parameters
alpha = 1.0; % Prey birth rate
beta = 0.1; % Predator success rate
gamma = 1.5; % Predator death rate
delta = 0.075; % Predator reproduction rate
% Define the symbolic variables
syms R W
% Define the equations
eq1 = alpha * R - beta * R * W == 0;
eq2 = delta * R * W - gamma * W == 0;
% Solve the equations
equilibriumPoints = solve([eq1, eq2], [R, W]);
% Extract the equilibrium point values
Req = double(equilibriumPoints.R);
Weq = double(equilibriumPoints.W);
% Display the equilibrium points
equilibriumPointsValues = [Req, Weq]
% Solve the differential equations using ode45
lotkaVolterra = @(t,Y)[alpha*Y(1)-beta*Y(1)*Y(2);
delta*Y(1)*Y(2)-gamma*Y(2)];
% Initial conditions
R0 = 40;
W0 = 9;
Y0 = [R0, W0];
tspan = [0, 100];
% Solve the differential equations
[t, Y] = ode45(lotkaVolterra, tspan, Y0);
% Extract the populations
R = Y(:, 1);
W = Y(:, 2);
% Plot the results
figure;
subplot(2,1,1);
plot(t, R, 'r', 'LineWidth', 1.5);
hold on;
plot(t, W, 'b', 'LineWidth', 1.5);
xlabel('Time (months)');
ylabel('Population');
legend('R', 'W');
grid on;
subplot(2,1,2);
plot(R, W, 'k', 'LineWidth', 1.5);
xlabel('R');
ylabel('W');
grid on;
hold on;
plot(Req, Weq, 'ro', 'MarkerSize', 8, 'MarkerFaceColor', 'r');
legend('Phase Trajectory', 'Equilibrium Point');
Now, we need to handle a modified version of the Lotka-Volterra equations. These modified equations incorporate logistic growth fot the prey population.
These equations are:
% Define parameters
alpha = 1.0;
K = 100; % Carrying Capacity of the prey population
beta = 0.1;
gamma = 1.5;
delta = 0.075;
% Define the symbolic variables
syms R W
% Define the equations
eq1 = alpha*R*(1 - R/K) - beta*R*W == 0;
eq2 = delta*R*W - gamma*W == 0;
% Solve the equations
equilibriumPoints = solve([eq1, eq2], [R, W]);
% Extract the equilibrium point values
Req = double(equilibriumPoints.R);
Weq = double(equilibriumPoints.W);
% Display the equilibrium points
equilibriumPointsValues = [Req, Weq]
% Solve the differential equations using ode45
modified_lv = @(t,Y)[alpha*Y(1)*(1-Y(1)/K)-beta*Y(1)*Y(2);
delta*Y(1)*Y(2)-gamma*Y(2)];
% Initial conditions
R0 = 40;
W0 = 9;
Y0 = [R0, W0];
tspan = [0, 100];
% Solve the differential equations
[t, Y] = ode45(modified_lv, tspan, Y0);
% Extract the populations
R = Y(:, 1);
W = Y(:, 2);
% Plot the results
figure;
subplot(2,1,1);
plot(t, R, 'r', 'LineWidth', 1.5);
hold on;
plot(t, W, 'b', 'LineWidth', 1.5);
xlabel('Time (months)');
ylabel('Population');
legend('R', 'W');
grid on;
subplot(2,1,2);
plot(R, W, 'k', 'LineWidth', 1.5);
xlabel('R');
ylabel('W');
grid on;
hold on;
plot(Req, Weq, 'ro', 'MarkerSize', 8, 'MarkerFaceColor', 'r');
legend('Phase Trajectory', 'Equilibrium Point');
While searching the internet for some books on ordinary differential equations, I came across a link that I believe is very useful for all math students and not only. If you are interested in ODEs, it's worth taking the time to study it.
A First Look at Ordinary Differential Equations by Timothy S. Judson is an excellent resource for anyone looking to understand ODEs better. Here's a brief overview of the main topics covered:
- Introduction to ODEs: Basic concepts, definitions, and initial differential equations.
- Methods of Solution:
- Separable equations
- First-order linear equations
- Exact equations
- Transcendental functions
- Applications of ODEs: Practical examples and applications in various scientific fields.
- Systems of ODEs: Analysis and solutions of systems of differential equations.
- Series and Numerical Methods: Use of series and numerical methods for solving ODEs.
This book provides a clear and comprehensive introduction to ODEs, making it suitable for students and new researchers in mathematics. If you're interested, you can explore the book in more detail here: A First Look at Ordinary Differential Equations.
The study of the dynamics of the discrete Klein - Gordon equation (DKG) with friction is given by the equation :
In the above equation, W describes the potential function:
to which every coupled unit 
adheres. In Eq. (1), the variable $
$ is the unknown displacement of the oscillator occupying the n-th position of the lattice, and 
is the discretization parameter. We denote by h the distance between the oscillators of the lattice. The chain (DKG) contains linear damping with a damping coefficient 
, while
is the coefficient of the nonlinear cubic term.
adheres. In Eq. (1), the variable $$ is the unknown displacement of the oscillator occupying the n-th position of the lattice, and is the discretization parameter. We denote by h the distance between the oscillators of the lattice. The chain (DKG) contains linear damping with a damping coefficient , whileis the coefficient of the nonlinear cubic term.For the DKG chain (1), we will consider the problem of initial-boundary values, with initial conditions
and Dirichlet boundary conditions at the boundary points 
and 
, that is,
and , that is,
Therefore, when necessary, we will use the short notation 
for the one-dimensional discrete Laplacian
for the one-dimensional discrete Laplacian
Now we want to investigate numerically the dynamics of the system (1)-(2)-(3). Our first aim is to conduct a numerical study of the property of Dynamic Stability of the system, which directly depends on the existence and linear stability of the branches of equilibrium points.
For the discussion of numerical results, it is also important to emphasize the role of the parameter 
. By changing the time variable 
, we rewrite Eq. (1) in the form
. By changing the time variable , we rewrite Eq. (1) in the form
. We consider spatially extended initial conditions of the form:
where 
is the distance of the grid and 
is the amplitude of the initial condition We also assume zero initial velocity:
the following graphs for 
and 
and % Parameters
L = 200; % Length of the system
K = 99; % Number of spatial points
j = 2; % Mode number
omega_d = 1; % Characteristic frequency
beta = 1; % Nonlinearity parameter
delta = 0.05; % Damping coefficient
% Spatial grid
h = L / (K + 1);
n = linspace(-L/2, L/2, K+2); % Spatial points
N = length(n);
omegaDScaled = h * omega_d;
deltaScaled = h * delta;
% Time parameters
dt = 1; % Time step
tmax = 3000; % Maximum time
tspan = 0:dt:tmax; % Time vector
% Values of amplitude 'a' to iterate over
a_values = [2, 1.95, 1.9, 1.85, 1.82]; % Modify this array as needed
% Differential equation solver function
function dYdt = odefun(~, Y, N, h, omegaDScaled, deltaScaled, beta)
U = Y(1:N);
Udot = Y(N+1:end);
Uddot = zeros(size(U));
% Laplacian (discrete second derivative)
for k = 2:N-1
Uddot(k) = (U(k+1) - 2 * U(k) + U(k-1)) ;
end
% System of equations
dUdt = Udot;
dUdotdt = Uddot - deltaScaled * Udot + omegaDScaled^2 * (U - beta * U.^3);
% Pack derivatives
dYdt = [dUdt; dUdotdt];
end
% Create a figure for subplots
figure;
% Initial plot
a_init = 2; % Example initial amplitude for the initial condition plot
U0_init = a_init * sin((j * pi * h * n) / L); % Initial displacement
U0_init(1) = 0; % Boundary condition at n = 0
U0_init(end) = 0; % Boundary condition at n = K+1
subplot(3, 2, 1);
plot(n, U0_init, 'r.-', 'LineWidth', 1.5, 'MarkerSize', 10); % Line and marker plot
xlabel('$x_n$', 'Interpreter', 'latex');
ylabel('$U_n$', 'Interpreter', 'latex');
title('$t=0$', 'Interpreter', 'latex');
set(gca, 'FontSize', 12, 'FontName', 'Times');
xlim([-L/2 L/2]);
ylim([-3 3]);
grid on;
% Loop through each value of 'a' and generate the plot
for i = 1:length(a_values)
a = a_values(i);
% Initial conditions
U0 = a * sin((j * pi * h * n) / L); % Initial displacement
U0(1) = 0; % Boundary condition at n = 0
U0(end) = 0; % Boundary condition at n = K+1
Udot0 = zeros(size(U0)); % Initial velocity
% Pack initial conditions
Y0 = [U0, Udot0];
% Solve ODE
opts = odeset('RelTol', 1e-5, 'AbsTol', 1e-6);
[t, Y] = ode45(@(t, Y) odefun(t, Y, N, h, omegaDScaled, deltaScaled, beta), tspan, Y0, opts);
% Extract solutions
U = Y(:, 1:N);
Udot = Y(:, N+1:end);
% Plot final displacement profile
subplot(3, 2, i+1);
plot(n, U(end,:), 'b.-', 'LineWidth', 1.5, 'MarkerSize', 10); % Line and marker plot
xlabel('$x_n$', 'Interpreter', 'latex');
ylabel('$U_n$', 'Interpreter', 'latex');
title(['$t=3000$, $a=', num2str(a), '$'], 'Interpreter', 'latex');
set(gca, 'FontSize', 12, 'FontName', 'Times');
xlim([-L/2 L/2]);
ylim([-2 2]);
grid on;
end
% Adjust layout
set(gcf, 'Position', [100, 100, 1200, 900]); % Adjust figure size as needed
Dynamics for the initial condition , 
, for 
, for different amplitude values. By reducing the amplitude values, we observe the convergence to equilibrium points of different branches from 
and the appearance of values 
for which the solution converges to a non-linear equilibrium point 
Parameters: 
, for , for different amplitude values. By reducing the amplitude values, we observe the convergence to equilibrium points of different branches from and the appearance of values for which the solution converges to a non-linear equilibrium point Parameters: 
Detection of a stability threshold 
: For 
, the initial condition , 
, converges to a non-linear equilibrium point
.
: For , the initial condition , , converges to a non-linear equilibrium point.Characteristics for 
, with corresponding norm 
where the dynamics appear in the first image of the third row, we observe convergence to a non-linear equilibrium point of branch 
This has the same norm and the same energy as the previous case but the final state has a completely different profile. This result suggests secondary bifurcations have occurred in branch 
, with corresponding norm where the dynamics appear in the first image of the third row, we observe convergence to a non-linear equilibrium point of branch This has the same norm and the same energy as the previous case but the final state has a completely different profile. This result suggests secondary bifurcations have occurred in branch By further reducing the amplitude, distinct values of 
are discerned: 1.9, 1.85, 1.81 for which the initial condition 
with norms 
respectively, converges to a non-linear equilibrium point of branch 
This equilibrium point has norm 
and energy 
. The behavior of this equilibrium is illustrated in the third row and in the first image of the third row of Figure 1, and also in the first image of the third row of Figure 2. For all the values between the aforementioned a, the initial condition 
converges to geometrically different non-linear states of branch 
as shown in the second image of the first row and the first image of the second row of Figure 2, for amplitudes 
and 
respectively.
are discerned: 1.9, 1.85, 1.81 for which the initial condition with norms respectively, converges to a non-linear equilibrium point of branch This equilibrium point has norm and energy . The behavior of this equilibrium is illustrated in the third row and in the first image of the third row of Figure 1, and also in the first image of the third row of Figure 2. For all the values between the aforementioned a, the initial condition converges to geometrically different non-linear states of branch as shown in the second image of the first row and the first image of the second row of Figure 2, for amplitudes and respectively. Refference:
The study of the dynamics of the discrete Klein - Gordon equation (DKG) with friction is given by the equation :
above equation, W describes the potential function :
The objective of this simulation is to model the dynamics of a segment of DNA under thermal fluctuations with fixed boundaries using a modified discrete Klein-Gordon equation. The model incorporates elasticity, nonlinearity, and damping to provide insights into the mechanical behavior of DNA under various conditions.
% Parameters
numBases = 200; % Number of base pairs, representing a segment of DNA
kappa = 0.1; % Elasticity constant
omegaD = 0.2; % Frequency term
beta = 0.05; % Nonlinearity coefficient
delta = 0.01; % Damping coefficient
- Position: Random initial perturbations between 0.01 and 0.02 to simulate the thermal fluctuations at the start.
- Velocity: All bases start from rest, assuming no initial movement except for the thermal perturbations.
% Random initial perturbations to simulate thermal fluctuations
initialPositions = 0.01 + (0.02-0.01).*rand(numBases,1);
initialVelocities = zeros(numBases,1); % Assuming initial rest state
The simulation uses fixed ends to model the DNA segment being anchored at both ends, which is typical in experimental setups for studying DNA mechanics. The equations of motion for each base are derived from a modified discrete Klein-Gordon equation with the inclusion of damping:
% Define the differential equations
dt = 0.05; % Time step
tmax = 50; % Maximum time
tspan = 0:dt:tmax; % Time vector
x = zeros(numBases, length(tspan)); % Displacement matrix
x(:,1) = initialPositions; % Initial positions
% Velocity-Verlet algorithm for numerical integration
for i = 2:length(tspan)
% Compute acceleration for internal bases
acceleration = zeros(numBases,1);
for n = 2:numBases-1
acceleration(n) = kappa * (x(n+1, i-1) - 2 * x(n, i-1) + x(n-1, i-1)) ...
- delta * initialVelocities(n) - omegaD^2 * (x(n, i-1) - beta * x(n, i-1)^3);
end
% positions for internal bases
x(2:numBases-1, i) = x(2:numBases-1, i-1) + dt * initialVelocities(2:numBases-1) ...
+ 0.5 * dt^2 * acceleration(2:numBases-1);
% velocities using new accelerations
newAcceleration = zeros(numBases,1);
for n = 2:numBases-1
newAcceleration(n) = kappa * (x(n+1, i) - 2 * x(n, i) + x(n-1, i)) ...
- delta * initialVelocities(n) - omegaD^2 * (x(n, i) - beta * x(n, i)^3);
end
initialVelocities(2:numBases-1) = initialVelocities(2:numBases-1) + 0.5 * dt * (acceleration(2:numBases-1) + newAcceleration(2:numBases-1));
end
% Visualization of displacement over time for each base pair
figure;
hold on;
for n = 2:numBases-1
plot(tspan, x(n, :));
end
xlabel('Time');
ylabel('Displacement');
legend(arrayfun(@(n) ['Base ' num2str(n)], 2:numBases-1, 'UniformOutput', false));
title('Displacement of DNA Bases Over Time');
hold off;
The results are visualized using a plot that shows the displacements of each base over time . Key observations from the simulation include :
- Wave Propagation: The initial perturbations lead to wave-like dynamics along the segment, with visible propagation and reflection at the boundaries.
- Damping Effects: The inclusion of damping leads to a gradual reduction in the amplitude of the oscillations, indicating energy dissipation over time.
- Nonlinear Behavior: The nonlinear term influences the response, potentially stabilizing the system against large displacements or leading to complex dynamic patterns.
% 3D plot for displacement
figure;
[X, T] = meshgrid(1:numBases, tspan);
surf(X', T', x);
xlabel('Base Pair');
ylabel('Time');
zlabel('Displacement');
title('3D View of DNA Base Displacements');
colormap('jet');
shading interp;
colorbar; % Adds a color bar to indicate displacement magnitude
% Snapshot visualization at a specific time
snapshotTime = 40; % Desired time for the snapshot
[~, snapshotIndex] = min(abs(tspan - snapshotTime)); % Find closest index
snapshotSolution = x(:, snapshotIndex); % Extract displacement at the snapshot time
% Plotting the snapshot
figure;
stem(1:numBases, snapshotSolution, 'filled'); % Discrete plot using stem
title(sprintf('DNA Model Displacement at t = %d seconds', snapshotTime));
xlabel('Base Pair Index');
ylabel('Displacement');
% Time vector for detailed sampling
tDetailed = 0:0.5:50; % Detailed time steps
% Initialize an empty array to hold the data
data = [];
% Generate the data for 3D plotting
for i = 1:numBases
% Interpolate to get detailed solution data for each base pair
detailedSolution = interp1(tspan, x(i, :), tDetailed);
% Concatenate the current base pair's data to the main data array
data = [data; repmat(i, length(tDetailed), 1), tDetailed', detailedSolution'];
end
% 3D Plot
figure;
scatter3(data(:,1), data(:,2), data(:,3), 10, data(:,3), 'filled');
xlabel('Base Pair');
ylabel('Time');
zlabel('Displacement');
title('3D Plot of DNA Base Pair Displacements Over Time');
colorbar; % Adds a color bar to indicate displacement magnitude
Let S be the closed surface composed of the hemisphere 
and the base 
Let 
be the electric field defined by 
. Find the electric flux through S. (Hint: Divide S into two parts and calculate 
).
and the base Let be the electric field defined by . Find the electric flux through S. (Hint: Divide S into two parts and calculate ).% Define the limits of integration for the hemisphere S1
theta_lim = [-pi/2, pi/2];
phi_lim = [0, pi/2];
% Perform the double integration over the spherical surface of the hemisphere S1
% Define the electric flux function for the hemisphere S1
flux_function_S1 = @(theta, phi) 2 * sin(phi);
electric_flux_S1 = integral2(flux_function_S1, theta_lim(1), theta_lim(2), phi_lim(1), phi_lim(2));
% For the base of the hemisphere S2, the electric flux is 0 since the electric
% field has no z-component at the base
electric_flux_S2 = 0;
% Calculate the total electric flux through the closed surface S
total_electric_flux = electric_flux_S1 + electric_flux_S2;
% Display the flux calculations
disp(['Electric flux through the hemisphere S1: ', num2str(electric_flux_S1)]);
disp(['Electric flux through the base of the hemisphere S2: ', num2str(electric_flux_S2)]);
disp(['Total electric flux through the closed surface S: ', num2str(total_electric_flux)]);
% Parameters for the plot
radius = 1; % Radius of the hemisphere
% Create a meshgrid for theta and phi for the plot
[theta, phi] = meshgrid(linspace(theta_lim(1), theta_lim(2), 20), linspace(phi_lim(1), phi_lim(2), 20));
% Calculate Cartesian coordinates for the points on the hemisphere
x = radius * sin(phi) .* cos(theta);
y = radius * sin(phi) .* sin(theta);
z = radius * cos(phi);
% Define the electric field components
Ex = 2 * x;
Ey = 2 * y;
Ez = 2 * z;
% Plot the hemisphere
figure;
surf(x, y, z, 'FaceAlpha', 0.5, 'EdgeColor', 'none');
hold on;
% Plot the electric field vectors
quiver3(x, y, z, Ex, Ey, Ez, 'r');
% Plot the base of the hemisphere
[x_base, y_base] = meshgrid(linspace(-radius, radius, 20), linspace(-radius, radius, 20));
z_base = zeros(size(x_base));
surf(x_base, y_base, z_base, 'FaceColor', 'cyan', 'FaceAlpha', 0.3);
% Additional plot settings
colormap('cool');
axis equal;
grid on;
xlabel('X');
ylabel('Y');
zlabel('Z');
title('Hemisphere and Electric Field');
To solve a surface integral for example the
over the sphere 
easily in MATLAB, you can leverage the symbolic toolbox for a direct and clear solution. Here is a tip to simplify the process:
over the sphere easily in MATLAB, you can leverage the symbolic toolbox for a direct and clear solution. Here is a tip to simplify the process:- Use Symbolic Variables and Functions: Define your variables symbolically, including the parameters of your spherical coordinates θ and ϕ and the radius r . This allows MATLAB to handle the expressions symbolically, making it easier to manipulate and integrate them.
- Express in Spherical Coordinates Directly: Since you already know the sphere's equation and the relationship in spherical coordinates, define x, y, and z in terms of r , θ and ϕ directly.
- Perform Symbolic Integration: Use MATLAB's `int` function to integrate symbolically. Since the sphere and the function
are symmetric, you can exploit these symmetries to simplify the calculation.
Here’s how you can apply this tip in MATLAB code:
% Include the symbolic math toolbox
syms theta phi
% Define the limits for theta and phi
theta_limits = [0, pi];
phi_limits = [0, 2*pi];
% Define the integrand function symbolically
integrand = 16 * sin(theta)^3 * cos(phi)^2;
% Perform the symbolic integral for the surface integral
surface_integral = int(int(integrand, theta, theta_limits(1), theta_limits(2)), phi, phi_limits(1), phi_limits(2));
% Display the result of the surface integral symbolically
disp(['The surface integral of x^2 over the sphere is ', char(surface_integral)]);
% Number of points for plotting
num_points = 100;
% Define theta and phi for the sphere's surface
[theta_mesh, phi_mesh] = meshgrid(linspace(double(theta_limits(1)), double(theta_limits(2)), num_points), ...
linspace(double(phi_limits(1)), double(phi_limits(2)), num_points));
% Spherical to Cartesian conversion for plotting
r = 2; % radius of the sphere
x = r * sin(theta_mesh) .* cos(phi_mesh);
y = r * sin(theta_mesh) .* sin(phi_mesh);
z = r * cos(theta_mesh);
% Plot the sphere
figure;
surf(x, y, z, 'FaceColor', 'interp', 'EdgeColor', 'none');
colormap('jet'); % Color scheme
shading interp; % Smooth shading
camlight headlight; % Add headlight-type lighting
lighting gouraud; % Use Gouraud shading for smooth color transitions
title('Sphere: x^2 + y^2 + z^2 = 4');
xlabel('x-axis');
ylabel('y-axis');
zlabel('z-axis');
colorbar; % Add color bar to indicate height values
axis square; % Maintain aspect ratio to be square
view([-30, 20]); % Set a nice viewing angle
The stationary solutions of the Klein-Gordon equation refer to solutions that are time-independent, meaning they remain constant over time. For the non-linear Klein-Gordon equation you are discussing:
Stationary solutions arise when the time derivative term, 
, is zero, meaning the motion of the system does not change over time. This leads to a static differential equation:
, is zero, meaning the motion of the system does not change over time. This leads to a static differential equation:
This equation describes how particles in the lattice interact with each other and how non-linearity affects the steady state of the system.
The solutions to this equation correspond to the various possible stable equilibrium states of the system, where each represents different static distribution patterns of displacements 
. The specific form of these stationary solutions depends on the system parameters, such as κ , ω, and β , as well as the initial and boundary conditions of the problem.
. The specific form of these stationary solutions depends on the system parameters, such as κ , ω, and β , as well as the initial and boundary conditions of the problem.To find these solutions in a more specific form, one might need to solve the equation using analytical or numerical methods, considering the different cases that could arise in such a non-linear system.
By interpreting the equation in this way, we can relate the dynamics described by the discrete Klein - Gordon equation to the behavior of DNA molecules within a biological system . This analogy allows us to understand the behavior of DNA in terms of concepts from physics and mathematical modeling .
% Parameters
numBases = 100; % Number of spatial points
omegaD = 0.2; % Common parameter for the equation
% Preallocate the array for the function handles
equations = cell(numBases, 1);
% Initial guess for the solution
initialGuess = 0.01 * ones(numBases, 1);
% Parameter sets for kappa and beta
paramSets = [0.1, 0.05; 0.5, 0.05; 0.1, 0.2];
% Prepare figure for subplot
figure;
set(gcf, 'Position', [100, 100, 1200, 400]); % Set figure size
% Newton-Raphson method parameters
maxIterations = 1000;
tolerance = 1e-10;
% Set options for fsolve to use the 'levenberg-marquardt' algorithm
options = optimoptions('fsolve', 'Algorithm', 'levenberg-marquardt', 'MaxIterations', maxIterations, 'FunctionTolerance', tolerance);
for i = 1:size(paramSets, 1)
kappa = paramSets(i, 1);
beta = paramSets(i, 2);
% Define the equations using a function
for n = 2:numBases-1
equations{n} = @(x) -kappa * (x(n+1) - 2 * x(n) + x(n-1)) - omegaD^2 * (x(n) - beta * x(n)^3);
end
% Boundary conditions with specified fixed values
someFixedValue1 = 10; % Replace with actual value if needed
someFixedValue2 = 10; % Replace with actual value if needed
equations{1} = @(x) x(1) - someFixedValue1;
equations{numBases} = @(x) x(numBases) - someFixedValue2;
% Combine all equations into a single function
F = @(x) cell2mat(cellfun(@(f) f(x), equations, 'UniformOutput', false));
% Solve the system of equations using fsolve with the specified options
x_solution = fsolve(F, initialGuess, options);
norm(F(x_solution))
% Plot the solution in a subplot
subplot(1, 3, i);
plot(x_solution, 'o-', 'LineWidth', 2);
grid on;
xlabel('n', 'FontSize', 12);
ylabel('x[n]', 'FontSize', 12);
title(sprintf('\\kappa = %.2f, \\beta = %.2f', kappa, beta), 'FontSize', 14);
end
% Improve overall aesthetics
sgtitle('Stationary States for Different \kappa and \beta Values', 'FontSize', 16); % Super title for the figure
In the second plot, the elasticity constant κis increased to 0.5, representing a system with greater stiffness . This parameter influences how resistant the system is to deformation, implying that a higher κ makes the system more resilient to changes . By increasing κ, we are essentially tightening the interactions between adjacent units in the model, which could represent, for instance, stronger bonding forces in a physical or biological system .
In the third plot the nonlinearity coefficient β is increased to 0.2 . This adjustment enhances the nonlinear interactions within the system, which can lead to more complex dynamic behaviors, especially in systems exhibiting bifurcations or chaos under certain conditions .
The following expression 
gives the solution for the Helmholtz problem. On the circular disc with center 0 and radius a. For 
the plot in 3-dimensional graphics of the solutions on Matlab for 
and then calculate some eigenfunctions with the following expression.
the plot in 3-dimensional graphics of the solutions on Matlab for and then calculate some eigenfunctions with the following expression. 
It could be better to separate functions with 
and 
as follows
and as followsdiska = 1; % Radius of the disk
mmax = 2; % Maximum value of m
nmax = 2; % Maximum value of n
% Function to find the k-th zero of the n-th Bessel function
% This function uses a more accurate method for initial guess
besselzero = @(n, k) fzero(@(x) besselj(n, x), [(k-(n==0))*pi, (k+1-(n==0))*pi]);
% Define the eigenvalue k[m, n] based on the zeros of the Bessel function
k = @(m, n) besselzero(n, m);
% Define the functions uc and us using Bessel functions
% These functions represent the radial part of the solution
uc = @(r, t, m, n) cos(n * t) .* besselj(n, k(m, n) * r);
us = @(r, t, m, n) sin(n * t) .* besselj(n, k(m, n) * r);
% Generate data for demonstration
data = zeros(5, 3);
for m = 1:5
for n = 0:2
data(m, n+1) = k(m, n); % Storing the eigenvalues
end
end
% Display the data
disp(data);
% Plotting all in one figure
figure;
plotIndex = 1;
for n = 0:nmax
for m = 1:mmax
subplot(nmax + 1, mmax, plotIndex);
[X, Y] = meshgrid(linspace(-diska, diska, 100), linspace(-diska, diska, 100));
R = sqrt(X.^2 + Y.^2);
T = atan2(Y, X);
Z = uc(R, T, m, n); % Using uc for plotting
% Ensure the plot is only within the disk
Z(R > diska) = NaN;
mesh(X, Y, Z);
title(sprintf('uc: n=%d, m=%d', n, m));
colormap('jet');
plotIndex = plotIndex + 1;
end
end
This study explores the demographic patterns and disease outcomes during the cholera outbreak in London in 1849. Utilizing historical records and scholarly accounts, the research investigates the impact of the outbreak on the city' s population. While specific data for the 1849 cholera outbreak is limited, trends from similar 19th - century outbreaks suggest a high infection rate, potentially ranging from 30% to 50% of the population, owing to poor sanitation and overcrowded living conditions . Additionally, the birth rate in London during this period was estimated at 0.037 births per person per year . Although the exact reproduction number (R₀) for cholera in 1849 remains elusive, historical evidence implies a high R₀ due to the prevalent unsanitary conditions . This study sheds light on the challenges of estimating disease parameters from historical data, emphasizing the critical role of sanitation and public health measures in mitigating the impact of infectious diseases.
Introduction
The cholera outbreak of 1849 was a significant event in the history of cholera, a deadly waterborne disease caused by the bacterium Vibrio cholera. Cholera had several major outbreaks during the 19th century, and the one in 1849 was particularly devastating.
During this outbreak, cholera spread rapidly across Europe, including countries like England, France, and Germany . The disease also affected North America, with outbreaks reported in cities like New York and Montreal. The exact number of casualties from the 1849 cholera outbreak is difficult to determine due to limited record - keeping at that time. However, it is estimated that tens of thousands of people died as a result of the disease during this outbreak.
Cholera is highly contagious and spreads through contaminated water and food . The lack of proper sanitation and hygiene practices in the 19th century contributed to the rapid spread of the disease. It wasn't until the late 19th and early 20th centuries that advancements in public health, sanitation, and clean drinking water significantly reduced the incidence and impact of cholera outbreaks in many parts of the world.
Infection Rate
Based on general patterns observed in 19th - century cholera outbreaks and the conditions of that time, it' s reasonable to assume that the infection rate was quite high. During major cholera outbreaks in densely populated and unsanitary areas, infection rates could be as high as 30 - 50% or even more.
This means that in a densely populated city like London, with an estimated population of around 2.3 million in 1849, tens of thousands of people could have been infected during the outbreak. It' s important to emphasize that this is a rough estimation based on historical patterns and not specific to the 1849 outbreak. The actual infection rate could have varied widely based on the local conditions, public health measures in place, and the effectiveness of efforts to contain the disease.
For precise and localized estimations, detailed historical records specific to the 1849 cholera outbreak in a particular city or region would be required, and such data might not be readily available due to the limitations of historical documentation from that time period
Mortality Rate
It' s challenging to provide an exact death rate for the 1849 cholera outbreak because of the limited and often unreliable historical records from that time period. However, it is widely acknowledged that the death rate was significant, with tens of thousands of people dying as a result of the disease during this outbreak.
Cholera has historically been known for its high mortality rate, particularly in areas with poor sanitation and limited access to clean water. During cholera outbreaks in the 19th century, mortality rates could be extremely high, sometimes reaching 50% or more in affected communities. This high mortality rate was due to the rapid onset of severe dehydration and electrolyte imbalance caused by the cholera toxin, leading to death if not promptly treated.
Studies and historical accounts from various cholera outbreaks suggest that the R₀ for cholera can range from 1.5 to 2.5 or even higher in conditions where sanitation is inadequate and clean water is scarce. This means that one person with cholera could potentially infect 1.5 to 2.5 or more other people in such settings.
Unfortunately, there are no specific and reliable data available regarding the recovery rates from the 1849 cholera outbreak, as detailed and accurate record - keeping during that time period was limited. Cholera outbreaks in the 19th century were often devastating due to the lack of effective medical treatments and poor sanitation conditions. Recovery from cholera largely depended on the individual's ability to rehydrate, which was difficult given the rapid loss of fluids through severe diarrhea and vomiting .
LONDON CASE OF STUDY
In 1849, the estimated population of London was around 2.3 million people. London experienced significant population growth during the 19th century due to urbanization and industrialization. It’s important to note that historical population figures are often estimates, as comprehensive and accurate record-keeping methods were not as advanced as they are today.
% Define parameters
R0 = 2.5;
beta = 0.5;
gamma = 0.2; % Recovery rate
N = 2300000; % Total population
I0 = 1; % Initial number of infected individuals
% Define the SIR model differential equations
sir_eqns = @(t, Y) [-beta * Y(1) * Y(2) / N; % dS/dt
beta * Y(1) * Y(2) / N - gamma * Y(2); % dI/dt
gamma * Y(2)]; % dR/dt
% Initial conditions
Y0 = [N - I0; I0; 0]; % Initial conditions for S, I, R
% Time span
tmax1 = 100; % Define the maximum time (adjust as needed)
tspan = [0 tmax1];
% Solve the SIR model differential equations
[t, Y] = ode45(sir_eqns, tspan, Y0);
% Plot the results
figure;
plot(t, Y(:,1), 'b', t, Y(:,2), 'r', t, Y(:,3), 'g');
legend('Susceptible', 'Infected', 'Recovered');
xlabel('Time');
ylabel('Population');
title('SIR Model');
axis tight;
grid on;
% Assuming t and Y are obtained from the ode45 solver for the SIR model
% Extract the infected population data (second column of Y)
infected = Y(:,2);
% Plot the infected population over time
figure;
plot(t, infected, 'r');
legend('Infected');
xlabel('Time');
ylabel('Population');
title('Infected Population over Time');
grid on;
The code provides a visual representation of how the disease spreads and eventually diminishes within the population over the specified time interval . It can be used to understand the impact of different parameters (such as infection and recovery rates) on the progression of the outbreak .
The Symbolic Math Toolbox includes functions for solving, visualizing, and manipulating symbolic math equations. In combination with MATLAB’s Live Editor, it provides an easy, intuitive, and complete environment to interactively learn and teach algebra, calculus, and ordinary differential equations.
Starting with MATLAB R2021a, you can represent matrices and vectors in compact matrix notation with a new symbolic matrix variable data type. This enables a concise typeset display and show mathematical formulas with more clarity. Using them, you can show matrix- and vector-based expressions the way they are displayed in textbooks.
Contrast the visual difference between matrices of symbolic scalar variables and the new symbolic matrix variables:
The syms and symmatrix functions create symbolic matrix variables. To convert a symbolic matrix variable to an array of symbolic scalar variables, use symmatrix2sym. For an example, see Create Symbolic Matrix Variables.
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