SimBiology

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I have a dataset that contains one independent variable, time and four dependent concentration variables. These are kinetic traces. Two of these variables are titrated concentrations that change from one trace to the next. I would like to fit the entire dataset to my model however Simbiology does not allow datasets where the independent variable increases non monotonically. How do I fit the entire dataset globally? Attached is a 3D plot of the different traces. I would like to create surface with my model on it. Is this possible in simbiology. I suppose if I get the parameters I can do it manually using meshgrid and surf. However the parameters need to come from a global fit. There are no analytical solutions to the 6 set of coupled ODEs. It has to be done numerically. I have also attached the dataset.

I am trying to add a fixed term for a species in the diagram view, in order to have the term E (system of ODEs in attached image). Is it possible?