SimBiology

フォロー

I'm building a mathematical model for a biological process. I have a set of ODE's ready for analysis, but I can't find a way to give these equations straight to the Simbiology analyser withouth first creating a diagram in the Simbiology model builder and hoping the ODE it spits out is the same as the one I already have. Is there a way to do this?

In SimBiology I have constructed a simple 2 Compartment Model to describe drug distribution over a set time course. The Model uses 6 parameters. I have a set of 11 individual data sets for the drug, however they are taken from different disease stages (early & late) which can be quantified as the "Time stage of Disease". Previous literature has stated a relationship between the stage of the disease and drug accumulation. However the specific relationship is not known. How do I incorporate the stage of disease as a covariate into my model? I'm unclear how to specify a relationship between the stage and the parameter, most literature says to use a NLME model but again I'm unclear about the implementation of this