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How could I do simutanoues parameter fitting for two series experimental data and multiple datasets?

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Yu Zhuo
Yu Zhuo 2020 年 6 月 17 日
回答済み: Star Strider 2020 年 6 月 19 日
I have sets of ODEs and want to fit them for 2 series expermental data simutanouesly.
Basic idea is just like:
I have experimental mean data for compartment 2 and 3. Since the different doses were given in compartment1. So I seperated them into different datasets but they should share the same ka,k3,k23,k32.
How should I write the ofv for this case? How should I do parameter optimization next by using fminsearch or other tools?
  1 件のコメント
Alex Sha
Alex Sha 2020 年 6 月 19 日
Just confused about "Dose", "compartment" and "observation", do they correspond to a(1), a(2) and a(3) respectively in your ODE functions?


その他の回答 (1 件)

Alex Sha
Alex Sha 2020 年 6 月 18 日
Hi, post your data please, if possible
  2 件のコメント
Yu Zhuo
Yu Zhuo 2020 年 6 月 18 日
1) Since time points are different for observations in compartment 2 and 3, I am confused if it is approporiate to put NaN in the input matrix for fminsearch or other optimizer?
2) Since there are 3 datasets and different doses were given, I am also confused that how to define a function of dose? and let matlab know which input matrix is for which dataset?
Thanks in advance!


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