insulindemo_changing the value of body weight

Hello,

I am currently using the insulin demo from the Toolbox SimBio for "Type 2 diabetic".

I would like to know wether is possible to change from Matlab editor values of parameters like:

• the body weight
• the basal plasma glucose concentration

Kind regards,

Juliana GONZALEZ

[Jeremy Huard]

Hi Juliana,

Are you trying to run a parameter scan to simulate with different values of body weight and basal plasma glucose concentration?

Is your preference to run these using a script instead of using the Model Analyzer app?

Best,

Jérémy

[Carmen Juliana Gonzalez]

Hi Jérémy,

Thank you very much for your answer.

What I would like to do is to change as I said the values of the body weight and the basal plasma glucose concentration and run a Type 2 diabetic simulation. The reason why I run the script in the Matlab editor is because I know how to export the result of the simulation to a .csv file.

This is my script.

sbioloadproject('insulindemo', 'm1')
warnSettings = warning('off', 'SimBiology:DimAnalysisNotDone_MatlabFcn_Dimensionless');
variants = getvariant(m1);
type2 = variants(1)

mealDose = sbioselect(m1, 'Name', 'Single Meal');
set(mealDose,'Amount',125)
get(mealDose)
configset = getconfigset(m1,'active');
%configset.TimeUnits = 'hour'
%configset.StopTime = 7;
configset.TimeUnits = 'minute'
configset.StopTime = 2000;
normalMealSim = sbiosimulate(m1, configset, [], mealDose);
diabeticVar = sbioselect(m1, 'Name', 'Type 2 diabetic')
%Simulation of a single meal for a Type 2 diabetic.
diabeticMealSim = sbiosimulate(m1, configset, diabeticVar, mealDose);
normal_Time = normalMealSim.Time;
dt2_Time = diabeticMealSim.Time;
normal_data = normalMealSim.Data;
dt2_data = diabeticMealSim.Data;
N=[normal_data,normal_Time];
M=[dt2_data, dt2_Time];
writematrix(N,'normal_simbio.csv')
writematrix(M,'dt2_simbio.csv')

as you can see in my script I know how to change the dose and the simulation time. But to go one step further in the simulation I need to be able to change other values as I have said above.

Could you explain to me how I can export the results from the Model Analyzer app to a .csv file ?

Kind Regards,

Juliana GONZALEZ

[Jeremy Huard]

Hi Juliana,

in the Model Analyzer, you can drag and drop a SimData array from the Browser to a datasheet. This will display the simData in a tabular format:

Then, you can right-click on that table to save it to an Excel file:

To answer your original question, you can indeed simulate for different parameter values in a script. You have a couple of options for this but my recommendation would be to use a SimFunction. You will find an example here: Simulate Model of Glucose-Insulin Response with Different Initial Conditions

Best regards,

Jérémy

[Carmen Juliana Gonzalez]

Dear Jeremy,

Thank you very much for your answer.

I will try your suggestions.