I use the nlme model with exponential error and FOCE method of likelihood estimation to fit the PK data. I got the highest loglikeihood with this setting. But I also got a error/warning that
"Iteration limit exceeded in the Laplacian algorithm. Returning result of the final iteration"
What should I do to overcome this error. Should I even try to overcome this.? With this error, if I try to report the parameter estimate is it authentic.?
I am also attaching the algorithm settings of iteration with this question for reference regarding my settings.