SimBiology Desktop Fitting using Concentration and response time profiles
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Dear Support,
Would you please advise me how to fit parameters (Smax and SC50) in the following PD model
dR/dt = kin - kout* (1 + Smax*Cplasma/(SC50+Cplasma) )* R, with R(0)=100%
using the observed the time profiles of Cplasma and R?
An example of dataset for Cplasma and R is given below.
Time (h) Cplasma (ng/mL) R (Dimensionless)
0 0 100%
0.25 39.36 N/A
0.5 38.29 N/A
1 39.64 N/A
2 28.79 N/A
4 8.43 N/A
8 6.63 63%
24 4.29 67%
48 2.93 78%
Thanks in advance.
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Arthur Goldsipe
2018 年 6 月 14 日
編集済み: Arthur Goldsipe
2018 年 6 月 20 日
The SimBiology documentation includes several examples that show how to fit a model using the command-line function sbiofit. The documentation also includes an example showing how to fit a pharmacokinetic model using the SimBiology desktop's graphical interface.
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