image processing detect artifacts and removing it

Hi,
I want to compare pixel based DICOM with approximated geometry. However, I have some artifact showing other pixels in my samples. What is the most efficient way to remove those artifacts which are discontinuous and shown in Blue rectangles?
So far I used rgb to visualize both samples to seperate the pixels and geometry.
ed.png>>

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2017 年 9 月 27 日

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