How does SimBiology calculate the "lambda" in NCA?

I was wonder that How does SimBiology calculate the "lambda" in NCA?

When I use WinNonlin, I can choice the weighting option in linear regression (ex. unweighted, 1/y, 1/y^2).

Although SimBiology doesn't provide the weighting option, I think that Simbiology uses any one of above.

Thank you.

Answer 1

[Arthur Goldsipe]

Hi,

Currently (as of R2018b), SimBiology's NCA uses linear regression with all of the points weighted equally. I'm guessing that's what you would call "unweighted."

-Arthur

[Seokuee Kim]

Thank you for your prompt answer!!